New Curcumin Analogs Show Promise in Overcoming Drug-Resistant Cancer
Researchers have identified two curcumin analogs demonstrating significant potential in countering multidrug-resistant cancer mechanisms. The compounds show strong P-glycoprotein inhibition while maintaining favorable toxicity profiles according to recent findings.
Breakthrough in Cancer Drug Resistance Research
Scientific reports indicate that two novel curcumin analogs, PGV-5 and HGV-5, demonstrate significant potential in overcoming multidrug-resistant cancer mechanisms. According to the research published in Scientific Reports, these compounds exhibit enhanced binding affinity to P-glycoprotein compared to curcumin, potentially addressing one of the major challenges in cancer treatment—drug resistance.